TM Flow Intended Use:

• Measurement of Ankle Brachial Indices for the screening of Peripheral Artery Disease.
• Measurement of the Galvanic Skin response related to the sudomotor function.
• Mathematical Analysis of the Photoplethysmography for assessing:- The autonomic nervous system via Heart Rate Variability Analysis at the rest and during the Ewing Tests
  – The Endothelial function via the Photoplethysmography (PTG) Analysis.

TM Flow Main Markers

VASCULAR FUNCTION ASSESSMENT

• Arterial stiffness and Ankle Brachial Indices from the Volume plethysmography analysis.
• Endothelial FunctionPatented markers from mathematical analysis of the photoplethysmography spectral analysis. (Off label use).

AUTONOMIC NERVOUS SYSTEM ASSESSMENT

• Sudomotor Function Markers.
• Heart rate variability Analysis  (HRV).
• Cardiac Autonomic Reflex Tests:
  –  Valsalva Ratio,
  ​-  E/I Ratio ,
  –  K30/15 Ratio and
  ​-  Systolic Pressure Response to Standing.

TM Flow Clinical Validation

• PTG Spectral Analysis Markers to:​
  
  – The gold standard of Insulin resistance assessment.​
  – The Coronary angiography.
  – Vascular blood tests (CRP and fibrinogen).

• Cardiometabolic Score to the Oral Glucose Tolerance Test (OGTT).
• Sudomotor markers to the:
  – Small fiber Neuropathy Symptoms.
  – Microvascular disease (retinopathy).